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Cardiac Autonomic Neuropathy in the Diabetic Patient: Does ^sup 123^I-MIBG Imaging Have a Role to Play in Early Diagnosis?
2004
HighBeam Research

Objectives: In diabetes, extended adrenergic receptor stimulation with hyperglycemia and insulin deficiency is associated with cardiac autonomic dysfunction. Clinically evident diabetic cardiac autonomic neuropathy (CAN) is associated with a poor prognosis. Research studies indicate that autonomic function tests, which are traditionally used to diagnose diabetic CAN, are less sensitive than ^sup 123^I-metaiodobenzylguanidine (MIBG) imaging, particularly in the early stages of the disease. This established imaging technique makes use of the noradrenaline analog MIBG, which is radiolabeled with ^sup 123^I to assess the noradrenaline uptake-1 mechanism of the sympathetic nervous system. ...

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